Панды читают номера поплавок с комой
df.iloc[:,:].str.replace(',', '').astype(float)
Real Raccoon
df.iloc[:,:].str.replace(',', '').astype(float)In [ 9]: import locale
In [10]: from locale import atof
In [11]: locale.setlocale(locale.LC_NUMERIC, '')
Out[11]: 'en_GB.UTF-8'
In [12]: df.applymap(atof)
Out[12]:
0 1
0 1200 4200.00
1 7000 -0.03
2 5 0.00